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Interplay between DNA sequence and negative superhelicity drives R-loop structures

IGG students Robert Stolz and Maika Malig, published groundbreaking work describing the first modeling of so-called R-loop structures, the most abundant non-B DNA structures in mammalian genomes. Using a “first-principle” mathematical approach backed by experimental validation, the group from the Chedin and Benham labs at UC Davis elucidated the relative contributions of DNA sequence and DNA topology to R-loop formation.

Discovering Curiosity: Building Mini-Organs to Fight Pancreatic Cancer with New Faculty Chang-il Hwang

When a healthy cell turns cancerous a cascade of events enables the cancer to spread throughout the body. But its origin lies within a single progenitor cell.

“What goes wrong with that particular cell?” asked Assistant Professor Chang-il Hwang, Department of Microbiology and Molecular Genetics. “Something happens at the molecular level. One DNA molecule, or one protein molecule changes.”

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Outstanding Student - Sydney Wyatt

  • NSF GRFP Awardee 2018
  • UC Davis T32 Training Program in Molecular and Cellular Biology Awardee
  • Involved in Outreach and Communication with Science Says and UCD Bioscope

A biomarker for the rare neurodegenerative disorder Fragile X -Associated tremor/ataxia syndrome (FXTAS)

Marwa Zafarullah is a third-year Ph.D. student in the Integrative Genetics and Genomics (IGG) graduate program. She earned her bachelor’s in agricultural sciences at the University of Agriculture, Faisalabad, Pakistan and her master’s in IGG at UC Davis. She is currently working toward the development of a biomarker for the early diagnosis and progression of the nNeurological disorder called Fragile X -Associated tremor/ataxia syndrome (FXTAS). 

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Three Incredible Tales of Microbial Symbiosis

Imagine you want to write a superhero comic. Obviously you need the superhero, the star of the show. But what else do you need? How about a sidekick, someone who helps the hero out? What about people to save? Maybe an evil villain to fight?

In biology, the relationships between the superheroes and each of these characters (a sidekick, people to save, and a villain) are called “symbioses.”

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Zebrafish Reproductive Development May Hold Insights into Ovarian Cancer

With funding from the National Institutes of Health and the National Science Foundation, BMCDB Graduate Group member Associate Professor Bruce Draper, Department of Molecular and Cellular Biology, is studying zebrafish (Danio rerio) to learn about the genetics of sexual reproduction in vertebrates. Draper’s research, published in PLOS Genetics with postdoc and Dena Leerberg, ’17 Ph.D., may advance discoveries into the origins of ovarian cancer.